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Thermodynamic data on the conformational stability of proteins can be obtained using several chemical or physical perturbants, including chaotropic agents (guanidine hydrochloride, urea), hydrostatic pressure, and temperature
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. This indicates that dissociation of the GR dimer takes place in a narrow range of GdnHCl concentrations between 2
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. All sequence-specificity is localized to the high-q, short-wavelength regime
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. These interactions will be determined by the specific sequence or, more precisely, by native-state topology
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. Thermal denaturations were earned out at pH 2
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. Here, we compare the ANS binding capacity of the four azurin species to inquire how these modified features modulate the ice-induced perturbation of tertiary structure
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. To further demonstrate the use of fluorescence anisotropy decay, we probed TTR aggregation kinetics using time-resolved anisotropy
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. 5 A, we present results showing that the affinity between CPM-PLCß and Gß? at atmospheric pressure on lipid membranes is strong and matches the K^sub d^(app) (i
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. This is both natural and necessary, since data from kinetic experiments do just the same, but there is a danger in overlooking aspects of folding that rely essentially on the presence of many degrees of freedom
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. INTRODUCTIONRibonucleic acid (RNA) folding represents a critical step toward the generation of functional three-dimensional structures of RNA molecules
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. Retrospective analyses of observational data have suggested a hierarchy among conventional NSAIDs in their potential for gastrointestinal injury, but these differences can be attributed to variations in effective dose and channeling bias (Henry et al
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. t] is the random error term
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. Each prescription of a controlled substance can be made into several crimes
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. So if you're hot, increase your bets and go for it; if Lady Luck has taken a walk, pull back and bet the minimum for a while
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. In explaining such a "fallacy" on the player's part, Wagenaar (1988) suggested that "a preference for winning does not necessarily entail the mathematical normative concept and the narrow optimal strategy that follows from it" (p
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. In more than half of these visits the age of the patient was 18 to 34
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. For the overall sample, there was a negative and significant (r = -0
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. In this follow-up study, we were interested in the association between interpersonal forms of discrimination and the health of illicit drug users
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. Because amphetamine is considered the prototype stimulant, other compounds that have similar chemical structures and similar physiologic effects are often termed 'amphetamines' (Figure 2)
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- For all studies the following buffer was used: 30 mM Mops, 50 mM NaCl, 2 mM CaCl^sub 2^, pH 7
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. The dominant elasticity results from distortions in the average particle configurations and is thought to be entropic in nature (70)
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.INTRODUCTIONHigh-density lipoproteins (HDLs) are heterogeneous complexes of lipids and specific proteins (termed exchangeable apolipoproteins) that mediate cholesterol removal from peripheral tissues to the liver via the process termed reverse cholesterol transport (Fielding and Fielding, 1995)
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. major, because the size was similar to that of P
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.We next assessed the effects of Type 2 RP on the pricing decisions of the firms whose drugs were used to set the reference price (the unrestricted NSAIDs) or whose drugs were no longer fully reimbursed under the policy (the first and second line restricted NSAIDs)
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. "Medicare Prescription Drug, Improvement, and Modernization Act
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. The functional support measures were:* Quantity of Functional Support
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.The employment and income measures were:* Hours Worked
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. (24) (XPCOM stands for Cross-Platform Component Object Model, and is somewhat similar to Microsoft's COM or Component Object Model
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.MethodParticipantsParticipants were 12 undergraduate students at the University of Hong Kong
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. "Conduct disorder is usually indicative of something else the clinician should look for," she says
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. In Case #2, a loss of 13% body weight was associated with normalization of serum insulin and lipids during the program
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. Exp Cell Res 1992:200:379-92
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. None of our cases showed arterial thromboses
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. Snoring and sleep apnoea in men: association with central obesity and hypertension
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. They are research associate and faculty research fellow, respectively, at the National Bureau of Economic Research (NBER)
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