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A further increase in quenching efficiency was observed at 7 M GdnHCl (squares, K^sub SV^ = 40 M^sup -1^), indicating that even at 3 M GdnHCl the tryptophan residues of GR were still significantly protected from iodide quenching relative to the fully unfolded protein
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. Helix, sheet, and polyproline II frequencies and strong nearest neighbor effects in a restricted coil library
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. Conformational substates in proteins
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. The ?^sub 222^(t) data show slow unfolding on a timescale of 10^sup 2^-10^sup 3^ s (as compared to 10^sup -8^-10^sup -10^ s for the helix-to-coil transition in solution; Yang and Gruebele, 2003), implicating high free-energy barrier ?G*
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. The interesting and unexpected prediction of nonnative and positive ?-values emerges in just this case
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. Moreover, the quasi-docked species observed in our study appears to form very rapidly, with a rate constant that is two to four orders of magnitude faster than the value reported for formation of the intermediate for the immobilized 4WJ ribozyme under similar conditions (Tan et al
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. ; the BC Ministry of Health; and the Drug Information Association is acknowledged
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. 09 *(block)Mother closeness X(a) Father closeness (a)(b) Other adult family (b)(c) School (c)-1
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. 0Mean among those withany expenditures (SE)$9,247 (773)$9,549 (404)PhysicianMean (SE)$1,006 (38) $1,024 (24)Percent with expenditures89
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. Missing values assigned to the mean and controlled for by missing valueindicators; values not shown
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. A gender-specific definition of binge drinking among college students
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. Ricaurte GA, Yuan J, Hatzidimitriou G, and others
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- Of particular interest is the question of how preferential interactions in 8 M urea or 6 M GdnCl conspire to make these conditions mimic perfect solvents for proteins
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. Thermodynamics of protein interactions with urea and guanidinium hydrochloride
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. but decreased as the temperature was raised (data not shown)
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. Crystal structure of the phosphoenolpynivate-hinding enzyme I domain from the Thermoanaerohacter leiixcongensis PEP:sugar phosphotransferase system
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.Malin constructed the color image from three black-and-white negatives of CG4 taken through different filters
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.RESULTSspFRET histograms reveal subpopulations of docked and extended ribozyme conformersFluorescence resonance energy transfer (FRET) is the nonradiative transfer of excitation energy between donor and acceptor dyes with overlapping emission and absorption spectra
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.Perhaps the most prominent new possibility for inhaled medicine is in the field of diabetes treatment
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.Table 3: Sample Size and Annual Prescription DrugSpending before and after Drug Coverage Switch forMedicare Beneficiaries with Calendar-End Changesin Drug CoverageSample SizeYear beforeYear afterDifference(unweighted)Switch SwitchNGainers 60 60 --Nevers177 177 --Average totalRx spending (SE)Gainers $664 (125) $1,101 * (194) +65
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. PNT was also influenced by prior SPI among the outpatient sample, with greater drug problems preceding beliefs that treatment would be helpful
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. While adolescents and young adults constitute a large and growing proportion of individuals in drug treatment, additional research will be needed to insure that these findings generalize to an older population or a more representative sample of adolescents
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. New York: Cambridge University Press
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