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One of the best-documented cases of pleiotropy is the gene associated with sickle-cell disease
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. As can be seen, the RT^sup n^^sub 1^ values spread around RT^sup n^^sub 1^ [asymptotically =] 0
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. This work was supported by grants from The Nanotech Programme of the Swedish Defence Research Agency (M
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. Methylphenidate (Ritalin®), a schedule II substance, is associated with patterns of abuse similar to other psychostimulants
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. The D-isomer (dexfenfluramine) was purportedly responsible for the anorectic actions of fenfluramine and was also associated with fewer side effects than the racemic fenfluramine
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- Based on these findings, it is tempting to suggest that the changes monitored by far-UV CD were due to the proximity of residues in the tertiary structure of the whole intact EIC^sup sc^ structure, but not of the isolated domains (and then, in those modeled in this work)
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. The high response of tetrameric proteins may suggest a particular destabilization of the native structure associated to the oligomeric state, a perturbation probably related to dissociation of the subunits and exposure of previously buried hydrophobic regions
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. The reaction was followed for >300 h
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.[FIGURE 6 OMITTED]DiscussionLiterature describing the early stages of species belonging to the family Pinguipedidae (formerly Mugiloididae) is scarce
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.Malin constructed the color image from three black-and-white negatives of CG4 taken through different filters
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.Manuscript approved for publication 30 March 2004 by the Scientific Editor
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