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- In either case the conclusion is that in the frozen state the polypeptide structure of the putative binding sites has changed, becoming unable to host ANS or to enhance its fluorescence yield, as when the probe surrounding changes from rigid to mobile (26)
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. The observation of identical MSDs and identical MSDs changes with temperature (and thus force constants, (55)) for native and soman-inhibited HuBChE below 334 K (61°C) suggest that wells A and B (Fig
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. These measurements monitored the change in fluorescence of a dilute solution of labeled protein as freshly extruded LUVs were added
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. The consequent mutual but general attraction of the helices for each other permits the final diffusive search for the native state to take place in a two-dimensional space, rather than the full five-dimensional search configuration space of all the diffusive degrees of freedom available to the protein once the secondary structure has formed
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.Of course, it is not impossible to achieve the dimensional reduction we have outlined by using fully native, rather than nonnative interactions
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. Frenkel for helpful discussions and comments on the manuscript, and the Kavli Institute for Theoretical Physics for the hospitality of its program "Dynamics of Complex and Macromolecular Fluids", where the bulk of this work was done (preprint number NSF-ITP-02-55)
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.The average burst duration for the SL 4WJ at 10mM Mg^sup 2+^ was estimated from two-channel data acquired with time bins of 50 µs, by averaging the burst durations within each 500-µs rebinned point lying above a threshold of 40
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.Kassirer doubts most physicians' ability to remain unbiased when they receive gilts from pharmaceutical companies
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.With the exception of orlistat, which is not absorbed into the systemic circulation, obesity drugs should be avoided by women who are pregnant or breast-feeding
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