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For both Escherichia coli and human GR, it has been demonstrated that structural elements from both subunits in the dimer are important for catalysis, leading to the conclusion that the monomers are inactive (Schulz et al
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Thus, it is tempting to associate the higher affinity of the mutant binding sites to a less stable globular fold and conclude that their creation is favored by, or requires, structural plasticity
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Note that potential variation of the ^sup 15^N CSA between -150 and -200 ppm hardly affects RT^sup n^^sub 1^ (±3%), and thus does not affect the conclusions (22)
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The remaining charge of DNA is neutralized by other positively charged chemicals in cell fluid, where mono- and divalent cations comprise up to 1% of the cell weight
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However, the off-rate of the association was too slow to be physiologically relevant (~2 min), suggesting that other cellular processes might serve to reduce the off-rate
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Nonetheless, it underlines the importance for overall folding rates of free-energy structures along a folding pathway, in which successive fluctuations in entropy and energy create a sequence of intermediate states
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At 5 wt%, we observed that a continuous gel was not formed, as we had found with the higher polymer concentrations
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The donor-acceptor solutions used were 100 pM in donor concentration, ensuring that virtually all of the detected signals were due to single molecules
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Break it down by discussing the meaning of the individual words--"social" and "neuroscience
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The government offered prescription drug coverage to all social assistance recipients and seniors, and subsidized drug expenses exceeding $1,000 for nonseniors (British Columbia 2001)
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The most innovative ones have the potential to make the medicine they deliver more effective than ever
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National Association of State Mental Health Program Directors and National Association of State Alcohol and Drug Abuse Directors" [accessed November 16, 2002]
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The interactions between parental closeness and other adult family supports for girls as they relate to substance use are very similar to the interaction of father closeness and other adult family support for boys as it relates to depression (Figures 2, 4, and 6)
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There is no conclusive evidence of peer effects in the sexual behavior outcomes either (Table V)
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Despite the logistical difficulties in identifying entering students with binge drinking histories, our results suggest substantial benefits to ensuring that binge-drinking young men do not room together in their first college year
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)But in her most ambitious reform--one she calls the most important on her agenda--Angell goes too far
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The major steps in conducting the pilot intervention were:1
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(6)Web adaptation technology: Internet Explorer browser extensionsThe project's software architecture was based on the need for client-side transformations combined with a server-side database for storing user preferences
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It's true that they all know what you're searching for, but search sites know that anyway
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Also, of the study's 152 participants, 91
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165/0$399K($75K)264Primrose School n9/1$190K-2
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The resulting change in mood or behavior is the summation of these neuromodulations and is quite complex
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gov)--has information for students,young adults, parents, teachers, researchers, and healthprofessionalsPhysician Leadership on National Drug Policy(http://plndp
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(5)Master coaches do not jump right in and give suggestions to improve performance or deal with a disagreement
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Existing affiliations may reduce member autonomy to form additional cooperative relationships (e
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Participants also were asked which type of discrimination had most impacted their life
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"The Internet allows us to have an open, anonymous environment where people are able to speak freely and share their experiences, but it also means that we can make the effort to support what is said with references
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But before you switch, do understand that, as the default browser for so many users, much of the content on the Web is developed specifically for IE (using ActiveX components, VB script, or proprietary HTML tags)
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"Ask yourself, quite simply, whether you've received the service you expected," says Sebastian Moser, U
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- Two months later, the surface fish with a transplanted cave-fish lens had a highly degenerated eye
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. Minimization of the mean-field free energy with respect to R^sub g^ yields a power law with a scaling exponent of v = 0
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. Instead, it exploits the lower energy state of the entire (d - n - 1)^sup th^ dimensional subspace to reach it via a one-dimensional diffusion in the (d - n)^sup th^ dimension, which it performs first
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. Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding
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. "Lowering the population's cholesterol by just a little bit produces a huge public health advantage
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." An examination of this category (n = 48) showed that for both boys and girls, 51% reported going to a sibling under 18 years; 18% indicated an extended family member; 14% reported friend/boyfriend; and 6% reported turning to their pets when personally troubled
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. Specifically, those in remission for depression at any follow-up had lower average HIV drug-risk scores (b=-
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