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Generation of conformational ensembles We have adapted conventional Markov-chain Metropolis Monte Carlo simulation strategies (60,61) to generate equilibrium ensembles for each of the protein sequences in the EV limit
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. Crystal structure of Escherichia coli malate synthase G complexed with magnesium and glyoxylate at 2
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. Effect of tumor necrosis factor antagonism on allergen-mediated asthmatic airway inflammation
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. Effect of process conditions on recovery of protein activity after freezing and freeze-drying
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. According to the simple ?^sup 7/4^ law proposed by Hoult (50), a SNR increase by 50% is expected between 14
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. Solution structures of the R6 human insulin hexamer
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. Simple versions of these models have indeed been able to account rather well for folding rates as a function of secondary structure formation (Myers and Oas, 1999, 2001)
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. The sizes of the primary particles in the gel ranged from 0
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. OpioidsOxyContin[R] and Vicodin[R] are opoiods
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. I KNEW I HIT ROCK BOTTOM WHEN I AWOKE TO FIND MY DOG EATING MY FOOT
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. Drug trialsCharles PetersWe have often complained about the failure of the FDA to make sure that once drugs are approved for marketing, there are follow-up studies to see how the drugs perform and to identify whatever unanticipated side effects might develop
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. METHODSDescription of the Study Site and Participant PopulationBetween March 2000 and June 2002 we recruited participants in Rhode Island for a study of combined psychotherapy (cognitive behavioral therapy) and pharmacotherapy for the treatment of depression in out-of-treatment drug injectors
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. On stigma and its consequences: evidence from a longitudinal study of men with dual diagnoses of mental illness and substance abuse
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. Trial and error: why we should drive the drug industry out of the clinical test businessMerrill GooznerThe Truth About the Drug Companies: How They Deceive Us and What To Do About It By Marcia Angell Random House, $24
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. Platensimycin "preexisted in nature to get this job done," Brown says
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. "It undermines the whole basis for the war on drugs and makes it a strictly scientific/medical issue"Whatever their reasons, law enforcement officials (along with most of the public and many physicians) still cling to the old-fashioned view of addiction as a biochemical process that inevitably results from extended use of certain drugs
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. The counterattacks may be having some effect
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. 57); "Awareness and openness" also correlated strongly with "Readiness to refer" (0
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. Stone suggests we all admit to three things:1
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. State and federal government agencies are also major sources of external support for drug abuse treatment centers
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. Philadelphia: Lippincott, Williams and Wilkins, 2002
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. 27From 1993 to 1997, the FDA received over 800 AERs (primarily cardiovascular, neurological, and psychiatric) of illnesses and injuries associated with the use of more than 100 different ephedra-type alkaloid dietary supplements
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. Several other factors are associated with the likelihood of Internet job searching
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. Levy and Louis-Robert Frigault, UQAM, Canada; Alain Leobon, Unite Mixte de Recherche Espace et Societe du CNRS Laboratoire CARTA, FranceThe internet has become an important tool for communication and meeting sexual partners among gay men, but few studies have addressed these topics in Quebec
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. For each of the six subjects tested--math, reading, science, language, spelling, and social studies--we calculated three separate measures of school-level achievement: the mean test score in the school, the fraction of students scoring above the 75th percentile score for the nation, and the fraction of students scoring above the 25th percentile score for the nation
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. The emperor's virtual clothes: The naked truth about internet culture
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- The large-scale fluctuations that give rise to the contact density maps shown in Fig
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. Functional interactions between proteins of the phosphoenolpyruvate:sugar phosphotransferase systems of Bacillus subtilis and Escherichia coli
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., K^sub p^ ~ 70 as opposed to 10 µM; Philip and Scarlata, 2004)
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. CARR1School of Polymer, Textile and Fiber Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, U
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