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Abbreviations used: CD, circular dichroism; DTNB, 5,5'-dithiobis-(2-nitrobenzoic) acid; EDTA, ethylenediaminetetracetic acid; GdnHCl, guanidine hydrochloride; GR, yeast glutathione reductase; GSH, reduced glutathione; GSSG, oxidized glutathione; HEPES, n-(2-hydroxyethyl) piperazine-n'-(2-ethanesulfonic acid); HPLC, high performance liquid chromatography; MG, molten globule
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The experimental results indicate that at physiological pH, the dimeric EI^sup SC^ had a well-folded structure; however, at low pH, EI^sup SC^ showed a partially unfolded state with the features of a molten globule, as suggested by fluorescence, far-ultraviolet circular dichroism, FTIR, and 8-anilino-1-naphthalene-sulfonic acid binding
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Crystal structure analysis of oxidized Pseudomonas aeruginosa azurin at pH 5
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and inelastic neutron scattering experiments (10)
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Higher pressures (usually above 5 kbars) will result in penetration of solvent into the protein matrix, resulting in a molten globule (e
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These rates are much faster than the overall rate constant for ribozyme docking observed in previous ensemble kinetic studies, which is on the order of 10^sup -2^ s^sup -1^ for a 2WJ ribozyme construct (N
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Energetics of hydrogen bond networks in RNA: Hydrogen bonds surrounding G+1 and U42 are the major determinants for the tertiary structure stability of the hairpin ribozyme
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CALGON TROPICAL DREAM BODY MIST 8 OZ, $6
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The Experiment: Social Environment and Dopamine ReceptorsDescription* Researchers measured the number of dopamine [D
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We then estimated a GEE model to determine if gender differences in treatment effects were constant across the three follow-up assessments; the second-order treatment by gender by time interaction was not statistically significant (Wald [chi square] =46, df=2, p=793), indicating that gender differences in treatment effects could be summarized by a single parameter estimate
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For example, 6-month SPI scores are regressed on SPI, TX dose, PNT, and LSE measures from the 3-month wave; while 6-month PNT scores are regressed on PNT, and LSE measures from the 3-month wave, as well as SPI and TX dose measures reflecting experiences preceding the 6-month wave
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Only a tiny fraction of the nation's nearly I million health care professionals licensed to prescribe controlled substances are willing to consistently use opioid medications, recognized as the best drugs for severe pain
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Her new doctor "is also under the microscope," she says
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There are special keyboards and mice available to ease difficulties with double-clicking and scrolling, but, in fact, these special devices provide only partial solutions to the problems experienced by older adults
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5 version the other night and it works just fine
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Enhanced with a comprehensive glossary of poker terms and slang, The Original Poker Diary will prove to be an invaluable addition to any serious poker player's personal reference shelf
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5K Pizza & Subs($15K/9
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4%NoneBAKERY PRODUCTS--MISCELLANEOUS57 Panera Bread/Saint5%None Louis Bread Co
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There is a re-enactment of that event each December at the home
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A growing number of pharmacists have been refusing to dispense birth-control pills and emergene/contraception (ECP) because it goes against their personal beliefs--and the law allows it
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Cross-tolerance occurs when a patient develops tolerance to a medication to which he or she has not been exposed because of tolerance developed to another chemical substance
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Metropolitan Life Insurance Company
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com--a proprietary, patent-pending technology--a clean, electronic prescription is sent to Rx
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"The American public does not fully, appreciate the value of medications, nor do they understand the role of the community pharmacist in helping to maximize the safe and effective benefits of their medications
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When the checks are completed, the pharmacist has three seconds to begin filling the hopper with pills
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* Women outvoted men in general 54 percent to 46 percent, according to a CNN 2004 voters' poll* In 2004, 51 percent of women voted Democrat versus 44 percent of men
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"We've been okay ever since
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2]=82, df=2, p=665) and 9-month ([W
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Rates dropped over time for both groups
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Starting in the first part of 2006, the new Series 60 browser will be available to all licensees as a standard application
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- This indicates that subtle conformational changes are induced by low concentrations of GdnHCl (The existence of partially folded intermediate states in the unfolding of GR is indicated by a comparison of fluorescence spectral shift, anisotropy, iodide quenching, and CD data as a function of GdnHCl concentration
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. We followed a three-part approach
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. These points and the liquid-glass transition boundary have been added to the nonequilibrium phase diagram (Fig
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. However, the PLCß^sub 2^ N-terminal PH domain allows for full activation by Gß?-subunits (Wang et al
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. On the other hand, seeding experiments suggest that mature, solid fibrils act as the most effective catalysts of amyloidogenesis in vitro (Harper et al
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., 1986; Neira, 1998; Leis and Rennis, 2000) and Prolatilus jugularis (Velez et al
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.2,295 2,071907 Kroger, Cincinnati3,413 1,750518 Safeway, Pleasanton, Calif
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. We need to build on those and try and test new things
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.Table 4 shows the results of separate multivariable models predicting change in the mental and physical health scores for each type of discrimination
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. treatment centers were randomly assigned to one of six psychosocial treatment interventions that were provided at no cost to participants
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. Among the hundreds of health-insurance providers and pharmacy benefit managers gearing up to introduce the new prescription-drug plans (see "Let the Bidding Begin," below) is PacifiCare Health Systems, which is spending an estimated $50 million this year to prepare itself internally to develop and market products, establish lists of preferred drugs, enroll and educate beneficiaries, and deal with mountains of federal regulations
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. Another is placed at the end of the line, to read all bottles in the case and to associate those bottles with that case
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. As shown in Figure 4, the TouchFree Switch provides an alternative to the physical switches often used by people with severe physical disabilities to control so-called scanning interfaces
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. In its breathless approximation of legitimate sports coverage, the production is hilariously WWFesque in a way that appeals perfectly to ironic 20-somethings: lots of gaudy money shots, a blonde "sideline reporter" who conducts exit interviews with ousted players, and "expert" announcers coming off as campy parodies of real sportscasters, with their nicknaming and jargonese
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.'"What is it about these machines that inspires such wrath? The chief complaint is that they are very good at fulfilling their primary mission: separating dopes from their money
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. And when you purchased a ticket, you had to fill out a form with your address and phone number on it
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.10 Interestingly, both MDMA and MDA were used therapeutically before being classified Schedule I in 1985
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. Waist circumference is best measured around the abdomen at the level of the iliac crest (29)
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.Illicit drug users may be particularly vulnerable to the many pathways through which discrimination is believed to harm health
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. Additionally, boys who reported feeling less close to their mother, but who go to other adults when personally troubled, reported the highest levels of substance use (Figure 8)
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. "Nature is telling us again and again that if you want to go after bacteria, go after this enzyme," he says
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. "You need both [executive and operations-level] perspectives to make sure you have the sponsorships but also that you can address the devil in the details," says Skrinar
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. (1,2) Fen-phen usage has attracted public attention in the United States, as it causes cardiac valvular lesions involving both the right-sided and left-sided cardiac valves, (3,4) We report the heart and lung autopsy findings in a documented case of PPH in a 36-year-old woman who received fen-phen for 7 months
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.At the next 2 monthly visits, he continued to give positive feedback and was losing weight at a rate of 12 lb per month
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. The psychosocial consequences of obesity include body image disparagement, impaired quality of life, and among the severely obese, depression (14, 15)
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. Options include regular dial-up service ($19
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