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DISCUSSIONThe effect of covalent inhibition by soman on the molecular dynamics of HuBChEThe structure and stability of the aged organophosphate conjugate of HuBChE produced by inhibition with soman are known to be modified compared to native HuBChE
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. This work was supported through the core strategic grant of the United Kingdom Biotechnology and Biological Sciences Research Council
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. Deposition of transthyretin in early stages of familial amyloidotic polyneuropathy: evidence for toxicity of nonfibrillar aggregates
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. Thus, the observed difference between the effects of apoA-1 and apoA-2 on the disk fusion may be important for the in vivo formation of LpA-1/A-2 which is proposed to involve LCAT-mediated fusion of small LpA-1 with LpA-2 (clay et al
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. However, it is not clear how applicable this approach is to cases in which secondary structure forms within a collapsed globule or cooperatively with it
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. 2 depends on two key physical assumptions: 1), the dimensionality of the space is of realistic values for protein folding-of the order of a hundred or more; and 2), the stability of the folded state is governed by completely cooperative local interactions in the native state only
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. One may drop the assumption of local forces and allow the protein to "fall" toward the single native state down a "funnel" created by forces whose range permeate the entire volume
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. For simplicity we assume that the kinetics of each diffusive search is single exponential with characteristic time ?
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. For this purpose each density value was standardized with respect to the maximum density observed for each survey season over all years
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. This latest report is the third in a series of documents exploring ways to ensure the safety of the U
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. "Having a rapid screening method to test for the presence of acetaminophen has the potential to shorten the length of time a patient is in the emergency department
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. In one recent investigation, Donohue and her colleagues examined insurance claims from 1997 to 2000 of more than 30,000 people with depression
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. Table 1 lists the determinants of these changes in expenditure per capita for all prescription drugs, and for the fastest growing therapeutic categories
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. Most (39 of 44) of the participants who met criteria for current cocaine abuse/ dependence also met criteria for current opiate abuse/dependence
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. The most frequent sources of this discrimination were mental disability, race, sexual orientation, and physical disability (40)
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. "In comparison to pedigree legislation in California and Florida, California does not exempt ADRs from passing pedigree and does require manufacturers to start the pedigree
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. "Even the DEA admits that 30 to 50 million people are undertreated for pain," says Ronald Libby, a professor of political science at the University of North Florida who has studied the issue
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. "I have to live where I have the most business," he says
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. The mean reward was HK$20
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. Pyruvate (1 mM), dexamethasone (10^sup -7^ M) and 10 ng/ml TGF-[beta]1 (recombinant human, R&D Systems, Abingdon, UK) were also added
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. BOTH DOCTORS and patients are demoralized these days, says Arthur Frank, though neither group is aware of what the other is experiencing
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. Not unlike other marginalized groups, illicit drug users may be especially vulnerable to health and other consequences of discrimination because they frequently possess multiple stigmatizing attributes such as homelessness or having spent time in jail or prison
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. Fluid check: drug test debunkingJacob SullumNEARLY TWO DECADES after drug testing started catching on in U
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. "Every time there is one of these trials," says Libby, "another 50 to 60 doctors drop off from prescribing
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. 1 billion, and almost no one except Wyeth expects the increases to stop there
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. A popular variation on oral ingestion is 'parachuting', in which a tablet is crushed, wrapped in tissue paper, and swallowed for more rapid absorption
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. World wide wonder? Measuring the impact of Internet subsidies to public schoolsAustan GoolsbeeLike the television revolution, which brought electronic boxes into schools in the 1960s and was supposed to turn classroom teaching on its head, computers were rolled into schools in the 1990s and connected to the worldwide web with the expectation that education would never be the same
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. In contrast, schools with 75 percent or more of their students eligible for the lunch program had a mere 8 percent of classrooms wired (see Figure 1)
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- Structure and stability of an early folding intermediate of Eschericliia coli Trp aporepressor measured by far-UV stopped-flow circular dichroism and 8-anilino-1-naphthalene sulfonate binding
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. The aceturate signal in the animal cytoplasm is much lower than that in the nucleus and increases only slowly
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. It was compared to a native HuBChE sample, denoted HuBChE-H2O (0
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. Therefore, the increase in reflow temperature results in better wettability with NC and WS fluxes
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.The prolonged 10-min incubation at 60°C promotes further elongation of the fibers even up to 2
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. Here, we report a method for identifying P
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.The study found that more than two-thirds (68 percent) of pharmacists support generic substitution for-brand name drugs in most cases, and about one-third (32 percent) said they support generic substitution for brand name drugs in all cases where a generic is available
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.(d) Normative data are based on values from the Monitoring the FutureStudy of 8th graders in 2000 (http://www
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. But we were the ones who suffered
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.Kelly had never been in trouble with the law and she had never been involved with drugs
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." Prosecutors said Hurwitz was "no better than a street corner crack dealer" who "dispenses misery and death
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.Extra-Vehicular ActivitiesWhen you’re ready to take a break from San Andreas’ story, there are dozens of minigames to keep you busy
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.Refer to physical therapy, counseling, or nutrition support, as appropriate
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. As such, he has become a defiant lightning rod for the growing movement among states, local governments and seniors' groups to seek lower-cost drugs from Canada, despite federal and state prohibitions governing the importing of medicines
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."Generally we support automation, particularly that automation that helps the pharmacist then focus on their clinical role," said Susan Winckler, vp for policy and communications at the American Pharmacists Association, a society of more than 53,000 pharmacists
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. Age-specific expenditures increased more rapidly for males (77 percent) than for females (73 percent)
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. "Joint Ventures: Theoretical and Empirical Perspectives
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.886drank in high schoolRoommate nonresponse to follow-upsurveyRespondent characteristics (all gathered in entering student survey)Black-
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. Policy interventions, low-level equilibria and social interactions
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. Scholze P, Norregaard L, Singer EA, and others
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. Moreover, valvular abnormalities present at baseline rarely progressed during the next year
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. Another possibility is inadvertent harm, such as relapse precipitated by a prescribed medication that altered the patient's vigilance and judgment
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. On the internet, then, there emerges a critical distinction, between typing, doing, and being!Text and Romanticism: A Literature of HopeIt may be argued that by its emphasis on text, the internet is atypical since most sexual interaction is verbal
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. Microsoft Internet Explorer, the dominant browser since the first Great Browser War (against Netscape Navigator), is seeing its commanding market share (88
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. In the past, Opera relied on search as only one part of its model but has now made agreements with search firms like Google, allowing the company to drop banner ads and user fees
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. "We're joining Firefox in the crusade to win IE users
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.Companies are even experimenting with innovative (and some would add, evil) technologies to use Bluetooth to "beam" commercial messages into unsuspecting users' Bluetooth devices
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