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. The four hinge regions create a flexible CaM dimer that can easily slide along or wobble over the peptide sequence allowing it to interact with the different binding sites in the interior of the CaM dimer
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. 33 K/min is sigmoidal and reaches a plateau at high temperatures, suggesting that the unfolding transition is complete at 99°C, yet the light-scattering curve recorded in the same experiment does not reach a plateau, and the signal continues to increase upon cooling from 99°C (Fig
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. Entropy estimation from simulations of non-diffusive systems
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. Unidentified pelagic fish eggs from open water were collected by using a plankton net (MTD net, NGG54 with mesh size of 0
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. com's front-end merchandise, excluding commodities like toothpaste and aspirin, is more than $50 and is going up
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. Curbing counterfeit drugsIn June 2006, the Food and Drug Administration's Counterfeit Drug Task Force released a new report on ways to curb the growing problem of counterfeit drugs
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. WRAP-UP* Conclude the lesson by asking students what they think ought to be done to end prescription drug abuse in their community
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. * SHE DIDN'T TELL THE JUDGE ROGER WAS A M
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. At the same time, the effects of government revenues indicate that pressures to improve effectiveness and efficiency have the same consequences in the drug abuse treatment sector as in other human services (Miller et al
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. 86Homeless (past 6 months): n (%) 503 50
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. "There's a lot of risk in the supply chain now in counterfeiting and diversion
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. Finkel's maturation from a fat, nerdy, obnoxious teenager to an ice-cool professional gambler is interesting to watch, but forgive me if I don't necessarily see this as a classical redemption story
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. All companies, regardless of size, are judged by the same criteria
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. These findings were anchored by a recent 6-month prospective, two-arm, randomized, double-blind, placebo-controlled safety and efficacy trial of a 90-mg ephedrine-type alkaloid, 192-mg caffeine product used in overweight but otherwise healthy subjects who were also enrolled in a protocol invoking healthy diet and exercise
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. " That approach, which he called the organization's newest project, is dubbed Continuing Professional Development, and it will include an Internet-based self-assessment exam, continuing education and management strategies "that will help pharmacists change their practices to effectively serve as their patient's medication advisor
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. Even as the baby boomer cohort threatens to swell the ranks of seniors entitled to public drug subsidy, the major drivers of expenditures and therefore public liability are endogenous to the pharmaceutical market
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. 05), but were equally likely to purchase any prescription drugs (86
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. The quarter of enrollment is always equal to zero
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. Given the high failure rate of IORs (Weiner and Alexander 1998; Kalmbach and Roussel 1999), this is a significant omission
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. The impact of depression on opiate users is extensive
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. 1 months (range 4-30 months) and showed a period between drug cessation and surgery of 17
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. Persons who abuse dextromethorphan, commonly adolescents, may develop respiratory depression and perceptual distortions while using the drug
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. 723Female * number of children1
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. Most participants were Montreal residents, single, and living alone
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- Assuming at least a qualitative relation between the absence of aggregation and larger red shifts for the unfolded states of BSUA, BLA, and BAA we can state the following: (1), the smallest heating rate (0
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. Address reprint requests to Chaejoon Cheong, Korea Basic Science Institute, 52 Eoun-dong, Yusung-gu, Daejeon 305-333, Korea
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. In the extreme, protein instability produces serum separation in the package and/or a meltdown that is curdy and shows whey separation
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. This study presents the multistage, hierarchical character of the spontaneous fibrillation of insulin at low pH and at 60 and 70°C, and-due to the marked enhancement of image resolution achieved-brings new clues as to the fibrils' ultrastructure and mechanisms of its assembly
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. Among first fibrillar features, short but relatively thick (8-nm) seedlike forms appeared on a very short timescale within the first minute of incubation
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., 1997; Sipe and Cohen, 2000; Jackson and Clarke, 2000; Serpell, 2000; Dobson, 2003; Rochet et al
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.3]t), t [greater than or equal to] April 1994 (7)Expected savings from [RP
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. A possible reason may be that being in an enriched environment had a positive influence on whether the monkeys took drugs
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. As a "theoretical breathing apparatus," the computer will simulate, i
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. While this allowed us to standardize, to some extent, structural factors that also may be associated with physical and mental health of the illicit drug users enrolled in this study, it also may limit the generalizability of the results documented here
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.294Quality of functional support 142
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.3 kg [9 lb, 7 oz]) after at least one year of sibutramine treatment than patients taking placebo
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. Evidence of substance use in early adolescence has been shown to predict late adolescent substance use and adult maladjustment (Stacy & Newcomb, 1999; Brook, Balka, Gursen, Brook, & Shapiro, 1997; Newcomb & Bentler, 1988; Kandel, Simcha-Fagan, & Davies, 1986)
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. Both male and female respondents entering college with a history of binge drinking report much more frequent binge drinking at the time of the follow-up interview than respondents entering college without a history of binge drinking
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. Repeat laboratory tests showed a normalized fasting insulin at 7 uIU/mL, as well as normalized lipids with a cholesterol of 192 mg/dL, triglycerides of 47 mg/dL, HDL of 50 mg/dL, and LDL cholesterol decreased to 134 mg/dL
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