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1 C) and the FTIR data acquired at pH 3 (Table 2)
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. Equilibrium NMR studies of unfolded and partially folded proteins
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. INTRODUCTION Freezing of protein solutions may result in irreversible protein aggregation and severe loss of catalytic activity of enzymes (1), a phenomenon of basic concern and of growing commercial importance for the expanding polypeptide-based pharmaceutical industry
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. Role of lipid packing in the activity of phospholipase C-deltal as determined by hydrostatic pressure measurements
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. Apolipoproteins obtained by this method retain full biological activity (Wetterau and Jonas, 1982)
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. In 2006, Lewin estimates that the mail-service pharmacy penetration rate will be about 23
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. Moreover, datasets such as the one used here could be used to assess drug use, safety, and outcomes in the real world with much greater detail than has been provided in this study
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. More specifically, we expect that drug abuse treatment centers affiliated with hospitals or mental health centers will be less likely to form IORs because these "parent" organizations may provide resources that obviate the need for drug abuse treatment centers to seek additional resources
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. PNT was also influenced by prior SPI among the outpatient sample, with greater drug problems preceding beliefs that treatment would be helpful
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. ) Disability Access to GNOME, The GNOME Project, http://developer
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. Directly below these buttons, the "Concept Reference" section held a dropdown list of concept identifiers for all previously viewed concepts and a "Go" button, which displayed details for the concept represented by the selected identifier
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. Schisandra has no known significant side effects
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. Department of Health and Human Services
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. Department of Health and Human Services
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. For girls, the interaction was not significant
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. We intend to explore possible mediational processes in our future work
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. Over time, though both groups reported significant increases in wages (p<
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. --BOB HERBERTCaille Millner is a reporter for the San Jose Mercury News
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. We tend to think of the 'Net as what we see in our browsers, often forgetting that the Web is really just one channel through which information flows over IP-based networks
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- Since the frequency of the solvent-exposed secondary structures is smaller than the buried ones (44,45), the above sequential events could be interpreted as follows: the unfolding of the solvent-exposed ß-sheet structures is the earliest event, followed by the formation of aggregates, and finally the unfolding of the other native structures
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. The studies show that there is no appreciable increase in the intensity of ANS fluorescence on dissociation to monomer or in the fully unfolded state (data not shown)
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. If the move is accepted, we set U = U', return to step 2, and iterate until convergence
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. Nature 2002; 418:200-203(20) Stuart LM, Ezekowitz RA
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. Equilibrium NMR studies of unfolded and partially folded proteins
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. We also employed the classic and widely used, although poorly understood, amyloid fluorescence dye ThT, which is known to interact with amyloid fibrils (Naiki et al
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., 1997; Sipe and Cohen, 2000; Jackson and Clarke, 2000; Serpell, 2000; Dobson, 2003; Rochet et al
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. The remarkable size may result from both the number of monomers involved, and the fact that insulin aggregation intermediates are rather bulky and swollen with water (Dzwolak et al
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. Although considerable evidence suggests that only partial destabilization of insulin is the prerequisite for its aggregation (Ahmad et al
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. Others have studied the effects of prior authorization programs targeting higher cost NSAIDs on the health-related quality of life (Momani, Madhavan, and Nau 2002) and medical services use (Kotzan et al
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.1 percent had abused Ritalin, and 5 percent said they had abused the powerful pain reliever OxyContin
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. However, we would argue there is also a need for a specialized KOS query API to take full advantage of applications with KOS-indexed metadata
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