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Taken together, these results suggest the existence of two molten-globule-like intermediate species (one dimeric and one monomeric) in the unfolding of GR
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. This process may ensue in widespread deformations of the native fold with the creation of a large number of ANS binding pockets
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. Consequently, they have a lower activation enthalpy of ~3
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. Indeed, the activity of compounds for inducing DNA phase separation is generally determined by their DNA binding potential
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. Transition state structure as a unifying basis in protein folding mechanisms: contact order, chain topology, stability and the extended nucleus mechanism
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. t] = 1] - E[[DaysNSDPop
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. The net effect of the changes in prescribing, patient expenditures, and drug prices was to reduce average Pharmacare expenditure per day of NSAID therapy by about half; the total volume of NSAIDs dispensed was unaffected
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. None of the surreptitiously recorded conversations with patients-turned-informants presented by the prosecution included any acknowledgment of the conspiracy Hurwitz supposedly led
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. " Next, with subjects having similar % rankings on several items, slightly more than a third of subjects agreed with the beliefs that "cravings/urges won't go away unless I use drugs," agreed they could not function without drugs, and believed their drug use was caused by someone else
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. Although still a mild psychostimulant, the behavioral effects of bupropion are reported to be unlike amphetamine when used in humans
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. Calapai G, Firenzuoli F, Saitta A, et al: Antiobesity and cardiovascular toxic effects of Ciirus auranlium extracts in the rat: a preliminary report
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. Sally Stipho MD * Andrew Artenstein MD Susan Potter MSN Marc Shapiro MD Liudvikas Jagminas MD Patricia Russo-Magno MD Eleanor Summerhill MD Memorial Hospital of RI/Brown Medical School, Pawtucket, RISelf-assessment:Knowledge ofPRE POSTbiologic agents(% of residents) (% of residents)None 31
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. "We are stunned by his testimony," they said
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. Participants were considerably less likely to meet criteria for current cocaine abuse or dependence; 35 (32
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. "PREPARE FOR RED TAPEOPTING TO PARTICIPATE, HOWEVER, means facing an array of administrative and communication choices associated with Medicare Part D
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. ) Uchino BN, Holt-Lunstad J, Uno D
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. "[ILLUSTRATION OMITTED]Given the trouble plaguing many large pharmaceutical companies these days, including Merck, it would be easy to discount Essner's confidence as hopeful speculation, but outsiders, too, are cautiously optimistic about Wyeth
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. It said many hackers now carry out criminal activities motivated by profit, whereas in the past they have shown a desire to demonstrate their skills
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- We use our results to resolve between conflicting proposals for structure in ensembles for highly denatured states
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. In experiments aimed at detecting the burial of the aromatic residues upon binding to PEP and/or Mg^sup 2+^, the concentration of EI^sup sc^ was 4 µM at pH 7
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. Among a large variety of different methods, such as absorption-, circular dichroism spectroscopy, calorimetry, NMR, and light scattering techniques, in particular fluorescence spectroscopy is a powerful technique to monitor unfolding transitions and to characterize properties of the unfolded state (see for example (3,4))
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. At high volume fractions there is a sufficient slowing of particle dynamics such that liquidlike configurations cannot be explored over practical timescales (5,6)
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.Structural polymorphism of mature fibrilsFig
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., neurotoxic protofibrils of ?-synuclein-Rochet et al
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. Entropic barriers, transition states, funnels, and exponential protein folding kinetics: a simple model
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. Most of the methanol was decanted, and the remaining methanol was allowed to evaporate
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. It is unclear if the increased opiate use is causally related to RP
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. "Social Structure and Alliance Formation Patterns: A Longitudinal Analysis
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.15 MDMA also exhibits nonlinear pharmacokinetics suggesting that beyond a certain threshold, small increases in dose may result in larger increases in blood concentrations with greater risk of toxicity
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. Because tricyclic antidepressants have a sedative effect, they should be used with caution in this population
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. Foster GD, Wadden TA, Makris AP, Davidson D, Swain Sanderson R, Allison DB, Kessler A
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.The focus of this paper is on how peers affect drug use and problematic sexual behavior among college students
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., 1995), we defined binge drinking differently for males and females--five or more drinks in a row for males and four or more in a row for females
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." If a doctor writes prescriptions to order for money, trades drugs for sex, or prescribes drugs for resale, he is operating outside "the usual course of professional practice
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. However data concerning the neurotoxicity of MDMA have been inconsistent and one major study was even retracted after it was found that the toxicity in the study was brought about by methamphetamine rather than MDMA
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. N Engl J Mccl 2000; 343: 1833-8
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. London: Intercontinental Medical Statistics Health; 2003
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. The results suggest that the internet, in providing access to a great diversity of sexual practices, can contribute to a transformation of individuals' sexual scenarios
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