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The quaternary structure of GR in the presence of GdnHCl was also investigated by size-exclusion liquid chromatography
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- This widelycited result provides the theoretical basis for the assertion that denatured proteins are Flory-like random coils (3,4,11,12,17,37,30)
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. 12 support the conclusion that EV limit ensembles are topologically equivalent
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. Lovastatin enhances clearance of apoptotic cells (efferocytosis) with implications for chronic obstructive pulmonary disease
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. This ~90° rotation of the diffusion tensor together with the relatively small structural changes within each CaM domain puts direct restraints on the overall structure of the CaM:SEF2-1mp complex, which allows us to choose one of the two possible schematic structure models proposed in our earlier study (11) (see Figs
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. Clearly this coarse-grained level of model cannot pick up specific and discontinuously large shifts of the transition state, which in small proteins will often dominate particular cases
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. The entropy analysis was therefore performed on the last 8 ns of each simulation, using molecular configurations that are two picoseconds apart
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