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An important prediction of field theory is that all power laws are the result of correlations imparted by repulsive, steric (EV) interactions
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Folding and stability of El^sup sc^ in the absence of effectors Two unfolding mechanisms have been described in oligomeric proteins exposed to high temperatures or high concentrations of chemical denaturants at equilibrium (49-51): 1), dissociation followed by unfolding of the native or partially unfolded monomeric species; and 2), denaturation without the accumulation of the native dissociated species
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The resulting spectra from the nucleus and cytoplasm revealed different uptake kinetics for the two components of the drug and demonstrate that MR technology is on the verge of becoming a tool for cell biology
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We repeated this study in the absence of membranes using freshly dialyzed CPM-PLCß-Gß? and found that in solution the volume change increases to 78 ± 3 ml/mol
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J Health Soc Behav 1999; 40:208-230
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- How the dilatation symmetry of denatured states is broken under folding conditions will depend on a variety of factors including local biases for turns and short stretches of extended or helical conformations, the drive to sequester hydrophohic amino acids, and the achievement of specificity in side-chain packing (103)
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. There have been numerous attempts to develop models for conformations accessible to highly denatured proteins
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. Direct demonstration of structural similarity between native and denatured eglin C
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. The parameters that can affect the wettability were investigated through modeling and are discussed elaborately
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. However, this model suggests another physical source of positive values for ?, since it identifies nonnative interactions as potentially crucial in establishing folding rates
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. In the hypergutter model, the "transition state" is, by definition, the subspace after that which takes the longest time to search-the rate-determining step
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.DISCUSSIONComparison of spFRET histograms and ensemble trFRET measurementsOur spFRET results for the wild-type ribozymes show the presence of extended (undocked) and docked conformations, with relative populations that are strongly dependent on the Mg^sup 2+^ concentration
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. Another major problem identified in the report is the FDA's funding distortion that favors rapid approval over safety
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. In Canada, such changes are now rare, owing to "frozen" prices for large public drug formularies (Morgan, Barer, and Agnew 2003)
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. In our models, we normalize ybase by dividing each predicted value by the mean ybase in the main population-based sample
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.ACKNOWLEDGMENTSSupport for this research was provided by the Centers for Medicare & Medicaid Services (CMS) under Contract number 500-00-0032 TO#4
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.Employment IncomeThe quality of functional support was marginally associated with an increase in employment income (p=
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