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This two-stage scheme is similar to that from the chemical unfolding/ refolding studies of ACYI (18,19), which also indicated that there existed a dimeric, aggregation-prone folding intermediate
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. In order to test the hypothesis, human monolayer expanded chondrocytes which were surplus to clinical requirements for ACI were maintained in pellet culture and exposed to TGF-[beta]1 within a defined medium during culture for up to 14 days
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- However, protein unfolding may cause an increase in the average distance between tyrosine and tryptophan residues, thus minimizing energy transfer and allowing detection of tyrosine emission
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. Low temperature induced conformational changes of aminoacylase
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. at both excitation wavelengths, showed a bell-shaped profile, with a maximum at neutral pH (Fig
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. Hence, there are four hinge regions in the CaM dimer
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. This results in an orientationdependent interparticle force and the possibility of dipolar interactions
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. These diseases include the amyloidoses such as Alzheimer's disease and familial amyloidotic polyneuropathy (FAP)
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. Even small (~100 residue) proteins have a configurational space dimensionality of several hundred (think of the bond angles along the polypeptide main chain alone)
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. We initially followed the gross maturity stage scheme of Nichol and Pikitch (1994) for darkblotched rockfish (Sebastes crameri) but ultimately abandoned their classification of maturity stages in favor of the simplified maturity stages reported by Gunderson et al
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. Between group differences did not approach statistically significant levels (p=63)
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.1%) reportedexperiencing discrimination because of it
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.3 My opinion is established on the morphologic study of the lungs of 37 patients who died in Switzerland after having ingested aminorex fumarate (another weight-reducing pill) during the so-called aminorex epidemic reviewed by Gunners Pulmonary hypertensive vascular disease affected 582 patients in Austria, former West Germany, and Switzerland during a limited period: from 1965, when the drug was introduced, until 1968, when it was withdrawn from the market
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.Penalties for drug trafficking in Syria range from 20 years in jail to death sentences, but no drug-related executions have been carried out, reported The Associated Press
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. At each medication visit, participants received 1 month of study medication
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. Food and Drug Administration (FDA)? How could we provide accurate information and recommendations to concerned patients who were taking these medicines and would look to us for answers?We found the answers in another act of Mayo teamwork
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._______________________Arlington, VA: I downloaded the 1
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