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- Once the genes neither enhance nor hinder the organism's survival, the forces of natural selection that once maintained those genes in good working order no longer operate
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. This equivalence in average topologies of denatured states explains why it has been reasonable to ignore the denatured state when assessing the contribution of topology to folding rates for small two-state proteins
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. In less-polar environments of the tryptophan chromophore the stokes shift will be less pronounced as compared to more-polar surroundings
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. In soman-aged HuBChE, the organophosphoryl moiety remains covalently attached to the unfolded protein, and the salt-bridge between the protonated imidazole ring of His-438 and the negatively charged phosphoryl oxygens may contribute to the observed shift in the onset of unfolding to a higher temperature compared to the native enzyme
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. McLeishDepartment of Physics and Astronomy and Astbury Centre for Molecular Biology, University of Leeds, Leeds, United KingdomSubmitted November 4, 2003, and accepted for publication September 7, 2004
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. In each step, chloride salts of appropriate cations (Ca, Fe, and Mg) were dissolved in deoxygenated, CO2-saturated water
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. Second, by testing the main effect of social support on well-being, it is hypothesized that there will be a negative linear relationship between the number of domains of perceived adult supports and the outcome variables of depression and substance use, with more domains of perceived adult supports leading to better outcomes
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.Intrinsic MotivationThe three GMS subscales used to assess intrinsic motivations were summed to reach an overall intrinsic motivation score
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. As going bust shortens the game somewhat, the impatient Hong Kong participants may have used this as a strategy to reduce the length of the experiment
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. In descending order of expenditure, these categories were cardiovascular; nervous system; alimentary tract and metabolism; genitourinary system and sex hormones; and antiinfectives for systemic use
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. Additionally, advances are being made in time-release and sustained-release systems, which in some cases are being coupled to biofeedback to further improve efficacy
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. Lexington, MA: Lexington Books
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