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The amide I' bands were assigned according to previous publications (24) business finance option small .
4, and the molarity of guanidinium hydrochloride was determined by refractive index as described by Pace (20) business finance option small .
Determination of atomic mean-square displacementsThe elastic intensity (Eq business finance option small .
, close to the active-site gorge), while at the same time increasing fluctuations in some other part of the protein (see business finance option small .
Binding affinity of ANS, DCVJ, and ThT to early misfolded TTR oligomersSamples containing 1 µM total concentration of misfolded A-state TTR monomers packed into soluble oligomers harvested 2 h after misfolding initiation were used as bait for probe binding business finance option small .
Thermal denaturution of apoA-2:DMPC disks showed biphasic kinetics business finance option small .
The framework and specific examples discussed here suggest useful coarse-grained models of other families of proteins that may be simulated very efficiently, or even approached analytically, as we have done with the three-helix bundles business finance option small .
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